Rustbelt CFAR Publications
The Current Pipeline of Antiretroviral Therapy: Expanding Options and Filling Gaps.
Li Y, Choudhary M, Mellors JW. The Current Pipeline of Antiretroviral Therapy: Expanding Options and Filling Gaps. Infect Dis Clin North Am. 2024 Sep;38(3):395-408. doi: 10.1016/j.idc.2024.04.001. Epub 2024 Jun 13. PMID: 38876905
SARS-CoV-2 viral clearance and evolution varies by type and severity of immunodeficiency.
Li Y, Choudhary MC, Regan J, Boucau J, Nathan A, Speidel T, Liew MY, Edelstein GE, Kawano Y, Uddin R, Deo R, Marino C, Getz MA, Reynolds Z, Barry M, Gilbert RF, Tien D, Sagar S, Vyas TD, Flynn JP, Hammond SP, Novack LA, Choi B, Cernadas M, Wallace ZS, Sparks JA, Vyas JM, Seaman MS, Gaiha GD, Siedner MJ, Barczak AK, Lemieux JE, Li JZ. SARS-CoV-2 viral clearance and evolution varies by type and severity of immunodeficiency. Sci Transl Med. 2024 Jan 24;16(731):eadk1599. doi: 10.1126/scitranslmed.adk1599. Epub 2024 Jan 24. PubMed PMID: 38266109.
Viral and host mediators of non-suppressible HIV-1 viremia.
Mohammadi A, Etemad B, Zhang X, Li Y, Bedwell GJ, Sharaf R, Kittilson A, Melberg M, Crain CR, Traunbauer AK, Wong C, Fajnzylber J, Worrall DP, Rosenthal A, Jordan H, Jilg N, Kaseke C, Giguel F, Lian X, Deo R, Gillespie E, Chishti R, Abrha S, Adams T, Siagian A, Dorazio D, Anderson PL, Deeks SG, Lederman MM, Yawetz S, Kuritzkes DR, Lichterfeld MD, Sieg S, Tsibris A, Carrington M, Brumme ZL, Castillo-Mancilla JR, Engelman AN, Gaiha GD, Li JZ. Viral and host mediators of non-suppressible HIV-1 viremia. Nat Med. 2023 Dec;29(12):3212-3223. doi: 10.1038/s41591-023-02611-1. Epub 2023 Nov 13. PubMed PMID: 37957382; PubMed Central PMCID: PMC10719098.
Review: The Landscape of Antiviral Therapy for COVID-19 in the Era of Widespread Population Immunity and Omicron-Lineage Viruses.
Meyerowitz EA, Li Y. Review: The Landscape of Antiviral Therapy for COVID-19 in the Era of Widespread Population Immunity and Omicron-Lineage Viruses. Clin Infect Dis. 2024 Apr 10;78(4):908-917. doi: 10.1093/cid/ciad685. PMID: 37949817; PMCID: PMC11487108.
Development and validation of an ultra-high performance liquid chromatography-tandem mass spectrometry method for quantifying lenacapavir plasma concentrations: application to therapeutic monitoring.
West 3rd RE, Oberly PJ, Riddler SA, Nolin TD, Devanathan AS. Development and validation of an ultra-high performance liquid chromatography-tandem mass spectrometry method for quantifying lenacapavir plasma concentrations: application to therapeutic monitoring. J Chromatogr B Analyt Technol Biomed Life Sci. 2023;1230:123905. PMID: 37866010 PMCID: PMC10842204.
Development and validation of ultra-high performance liquid chromatography-tandem mass spectrometry methods to quantify antiretroviral therapy concentrations in human plasma for therapeutic drug monitoring.
West 3rd RE, Oberly PJ, Riddler SA, Nolin TD, Devanathan AS. Development and validation of ultra-high performance liquid chromatography-tandem mass spectrometry methods to quantify antiretroviral therapy concentrations in human plasma for therapeutic drug monitoring. J Pharm Biomed Anal. 2024;240:115932. PMID: 38198884 PMCID: PMC10922569.
Simultaneous quantification of five antiretrovirals in human tissues using ultra-high performance liquid chromatography-tandem mass spectrometry methods for therapeutic drug monitoring at the sites of action.
West 3rd RE, Oberly PJ, Saylor AJ, Riddler SA, Nolin TD, Devanathan AS. Simultaneous quantification of five antiretrovirals in human tissues using ultra-high performance liquid chromatography-tandem mass spectrometry methods for therapeutic drug monitoring at the sites of action. J Chromatogr B Analyt Technol Biomed Life Sci. 2024;1241:124164. PMID: 38823149 PMCID: PMC11215648.
Age-dependent acceleration of biological aging during pathogenic SIVmac infection.
Jasinska A, Sivanandham R, Murali Kilapandal, Venkatraman S, Xu C, Gordevicius J, Brooke RT, Sette P, He T, Brocca -Cofano E, Policicchio BB, Nayak K, Talwar S, Annapureddy H, Ma D, Apetrei C, Pandrea I. Age-dependent acceleration of biological aging during pathogenic SIVmac infection. The 25th International AIDS Conference in Munich, Germany. July 22-26, 2024. (Poster# LB04)
Deciphering the role of endothelial granulocyte macrophage-CSF in chronic inflammation associated with HIV.
Panigrahi S, Mayne E, Louw S, Funderburg NT, Chakraborty A, Jacobson JM, Carpenter SM, Lederman MM, Freeman ML, Sieg SF. Deciphering the role of endothelial granulocyte macrophage-CSF in chronic inflammation associated with HIV. iScience. 2024 Sep 11;27(10):110909. doi: 10.1016/j.isci.2024.110909. PMID: 39391731; PMCID: PMC11465086.
The cell biology of HIV-1 latency and rebound.
Mbonye U, Karn J. The cell biology of HIV-1 latency and rebound. Retrovirology. 2024 Apr 5;21(1):6. doi: 10.1186/s12977-024-00639-w. PMID: 38580979 PMCID: PMC10996279.
Structural rearrangements in the nucleus localize latent HIV proviruses to a perinucleolar compartment supportive of reactivation.
Kizito F, Nguyen K, Mbonye U, Shukla M, Luttge B, Checkley MA, Agaponova A, Leskov K, Karn J. Structural rearrangements in the nucleus localize latent HIV proviruses to a perinucleolar compartment supportive of reactivation. Proceedings of the National Academy of Sciences 2024. 121(18):e2202003121. PMID: 38669184 PMCID: PMC11067448.
Protocol for the intracellular immunofluorescence measurements of latent HIV reactivation in a primary CD4+ T cell model.
Mbonye U, Agaponova A, Yang M, and Karn J. Protocol for the intracellular immunofluorescence measurements of latent HIV reactivation in a primary CD4+ T cell model. STAR Protoc. 2024. 5(4):103398. PMID: 39425934 PMCID: PMC11513541.
New insights into transcription elongation control of HIV latency and rebound.
Mbonye U, Kizito F, Karn J. New insights into transcription elongation control of HIV latency and rebound. Trends in Immunology 2023; 44(1):60-71. PMID: 36503686.
Using Concept Mapping to Adapt and Tailor a Post-Incarceration Clinic Model for Sexual and Gender Minoritized Adults in Cuyahoga County, OH.
Creasy S, Rollins A, Avery A, Mintz L, Dauria EF. Using Concept Mapping to Adapt and Tailor a Post-Incarceration Clinic Model for Sexual and Gender Minoritized Adults in Cuyahoga County, OH. Poster presented at the 2024 Academic Consortium on Criminal Justice Health. Phoenix, AZ: April 11, 2024.